To whom must researchers report potential unanticipated problems that involve risks to others?

Researchers must report potential unanticipated problems that involve risks to others to the Institutional Review Board (IRB) because the IRB is responsible for ensuring the safety and ethical treatment of research participants. The IRB has the authority to review and approve research proposals, monitor ongoing research, and protect the rights and welfare of participants. When a researcher encounters an unanticipated problem that presents risks, it is crucial to inform the IRB so that appropriate actions can be taken, such as adjusting the study protocols or notifying participants.

While the research participants, funding agencies, and ethics committees have their roles in the research process, the primary responsibility for oversight and ethical considerations rest with the IRB. Reporting to the IRB ensures that any necessary evaluations and interventions can occur, maintaining compliance with ethical standards in research.